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Important role for aclam diplomates, aslap members and Other Friends

AMERICAN COLLEGE OF LABORATORY ANIMAL MEDICINE



ACLAM FOUNDATION – FULL PROPOSAL INSTRUCTIONS



Request for Proposals (RFP)



The ACLAM Foundation Committee members are pleased to announce our solicitation of research proposals in Laboratory Animal Science and Medicine. The deadline for the Full Proposal is

March 14, 2013

. Foundation research awards will be distributed in early July. In addition to the RFP instructions below, you can review

Grant Application Tips

at the bottom of these instructions.

Important role for ACLAM Diplomates, ASLAP Members and Other Friends



Please distribute this year’s RFP to as many investigators as possible and take an active role by submitting or soliciting submission of a grant letter of intent. The RFP and other Foundation information are available on the ACLAM web site.

Foundation Contact



Dr. Gregory P Boivin

Chairman, ACLAM Foundation

Wright State University

053 Health Sciences

3640 Colonel Glenn Highway

Dayton, OH 45435

Phone: 937-775-2792

Fax: 937-775-4868

E-Mail: gregory.boivin@wright.edu

ACLAM FOUNDATION GRANT INFORMATION



The

Mission of the ACLAM Foundation

is to expand the body of knowledge in the fields of laboratory Animal Science and Medicine through funding research grants. The ACLAM Foundation has developed a two-tiered system for competitive review of grant proposals. Submission of a letter of intent is followed by a request for a full grant proposal to selected applicants. The Foundation will fund studies in the following six laboratory animal research subjects:

• Analgesia/anesthesia

• Behavior/well-being

• Diagnostics/diseases

• Husbandry

• Refinement of animal models [Note: Emphasis is on Russell & Birch 3R’s – reduction, refinement, replacement - not on new research model development.]

• Zoonotic disease (see Elizabeth R. Griffin Research Foundation - below)

Successful grantees are encouraged to publish their results in peer-reviewed journals and must agree to provide summary research reports in lay language suitable for inclusion in ACLAM Foundation communications, fund raising solicitations and the ACLAM Newsletter.

Full Grant Proposal



• Following the first level of review, full grant proposals will be requested from selected applicants.

A

n electronic version

of the full proposal (disc or email gregory.boivin@wright.edu )

must arrive

no later than

March 14, 2013 at 5:00pm eastern time

.

You will receive a confirmation of receipt of your electronic submission

. If you do not get a confirmation please contact Dr. Boivin.



I.

Intent

The full grant proposal should be designed to convince the reviewers that the applicant has identified a significant question and has developed a logical research plan and knowledgeable research team to address the question. Specifically comment on the relevance of the proposed study to advance scientific knowledge in the fields of laboratory animal science and medicine and/or to benefit the health and well being of laboratory animals. See the Conditions of Award section below.

II.

Format

The full proposal document must comply with the format of the form provided:

• Four form pages covering project title, institutional contact information and signatures, investigator names, budget, budget justification, facilities and major equipment information

• The body of the proposal cannot exceed six letter size pages

• Select one of the six research subjects (see page 1)

• 11 point type or larger, 1 inch margins

• Strict attachment limits are detailed below.

III.

Content

The full proposal must include:

• The front page must contain all information and be signed

• Pre-approval from the Institutional Animal Care and Use Committee (IACUC) at the institution where the animal experiment(s) will be conducted prior to funding being provided

• Detailed budget, not to exceed $30,000 [PI salary requests should be limited to the minimum acceptable by the home institution, total salary requests representing the major budget item is also discouraged, separate animal purchase and per diem costs.] [

The Foundation does not provide money for

administrative overhead, indirect costs, major equipment, travel, or graduate student fees/tuition

.]

• Detailed budget justification, facilities, and major equipment available for the grant

• Specific Aims and Hypothesis

• Background and the relevance of the project (optional inclusion of preliminary data: although not required it is highly recommended)

• Review of the study question and specific research objectives

• Description of the research plan, with a time line for experiments (one year maximum)

• Attachments: Résumé and References

IV.

Attachments

are strictly limited to:

• Two-page résumé for the PI. Please include relevant publications and other research funding. (It is not required that the Foundation form be used.)

• One page résumé for each co- PI or collaborator. Please include relevant publications and research funding. (It is not required that the Foundation form be used.)

• One page pre-approval from the IACUC (International investigators will receive additional instructions by the Foundation staff). If IACUC approval is pending at the time of submission full approval will be required before funds are released.

• One page of References

V.

Review Process

Reviewers will evaluate full proposals based on:

• Scientific merit

• Consistency with the mission of the Foundation (see page 1)

• Expertise of the investigators and collaborators

• Appropriate animal use (compliance with the ILAR Guide for the Care and Use of Laboratory Animals)

• Feasibility of completion within the grant time limit (one year from the date of award)

• Adequacy of research facilities

• Appropriateness of the budget

• Please see Reviewer instructions on the aclam.org website if you would like more information

VI.

Conditions of Award



• Grants are made to host institutions, not individual investigators or their department. Accordingly, full proposals

must bear the signature

of an official authorized to sign for the applicant institution. The principal investigator must hold a doctoral-level degree (DVM/VMD, MD, DDS, PhD or equivalent), with the one

Husbandry research topic

exception noted above.

• Grants are funded on an annual basis. The Foundation does not provide money for administrative overhead, indirect costs, major equipment, travel or graduate student fees/tuition. The Foundation reviewers recognize that technician salaries are justified but they discourage excessive PI salary requests (please limit requests to the minimum accepted by the home institution) and discourage that total salaries be the major budget item. Future funding is dependent on research progress and a subsequent application to the ACLAM Foundation.

• Funded grant awards will be announced on the ACLAM web site (www.aclam.org) and to successful grantees by written letter in early

July

. Seventy-five percent of funding is provided at the time the grant is awarded. For payment of the last 25% of funding, a summary research report is required in lay language suitable for inclusion in ACLAM Foundation reports, fund raising solicitations and the ACLAM Newsletter. The Foundation Scientific Director must receive the final report no later than 90 days following the one-year anniversary of the grant award.

• Grant recipients are expected to publish their results in peer-reviewed journals and are required to present poster presentations at the ACLAM Forum following the year that the funding research project has been completed. The Foundation Scientific Director will provide guidance on ACLAM Forum poster presentations. If the investigator is unable to attend the forum the Scientific Director should be contacted for alternative options.

Research publications must acknowledge the support of the American College of Laboratory Animal Medicine Foundation and, when appropriate, the Elizabeth R. Griffin Research Foundation.



Summary



Invited Full Proposals Due

– March 14, 2013

Grants Awarded

- early July 2013

VII.

Elizabeth R. Griffin Research Foundation



High quality

research

proposals are solicited that address the broad area of

zoonotic diseases

in any laboratory animal species. Research funding from the Griffin Foundation is available for research studies of

zoonotic disease

(prevention or treatment) or

enhanced laboratory safety practices

(protection from zoonotic disease transmission). Working in conjunction with the ACLAM Foundation and utilizing the grant review mechanism outlined above, Griffin Board members will be involved in proposal reviews.

Background



The Griffin Foundation is named in memory of Elizabeth "Beth" Griffin, a researcher at the Yerkes Regional Primate Research Center, who died at 22 after contracting Herpes B virus infection. Beth's family established the Foundation to assist research that clearly defines current public health risks associated with zoonotic diseases, to provide a support network for individuals who have contracted or who are at risk of contracting zoonotic diseases, to provide a prevention/treatment/information network for professional organizations, to provide for research of more effective prevention and treatment of zoonotic diseases (especially Herpes B virus), and to promote safe and responsible scientific research involving the use of animals. For more information, see the Griffin Foundation web site (www.ergriffinresearch.org).

VIII.

Application Tips



Below are some tips to keep in mind when completing your application.

Purpose and Importance of the Study:

Propose a compelling topic that involves one or more animal species of major importance to biomedical research. Formulate a question whose answer will benefit animals, the personnel who care for animals, or the scientific validity of animal use. Comment on the relevance of the study to advance scientific knowledge in the fields of laboratory animal science and medicine and to benefit the health and well-being of laboratory animals. Specify how your particular study will solve or contribute to the field of knowledge.

Personnel:

Consider adding collaborators to your team to include a scientist who has a publication record in the area of interest. Consider adding preliminary data to demonstrate your ability to complete the grant and to show evidence of the validity of your research.

Experimental Design:

Flawed experimental design will derail an otherwise compelling proposal. Request that a statistician or an experienced investigator critique your experimental design to point out items that need further explanation; these colleagues will help you ensure that the study outcome will withstand scientific analysis. Specify all control groups (such as sham surgical controls, negative controls, and positive controls); if certain types of controls are absent, explain the rationale for each omission. Be explicit but brief in your experimental design description; experimental group and treatment listings may be portrayed succinctly in a table. Consider how you will avoid observer bias, order/sequence bias, and environmental effects.

Experimental Methods:

Address all issues that pertain to animal welfare, and explain any deviations from best available practices for animal handling, anesthesia, analgesia, or animal care. Indicate what types of data will be collected, including the frequency, method, volume, and duration of sample collection from animals, and use the best available data collection methods. Refinements such as automated or implantable devices for physiologic monitoring, sample collection, or sustained drug delivery often provide superior data compared with other methods. Explain methodology for critical phases of study. If "natural exposure" to an infectious agent is proposed for animals, explain how such exposure is achieved or mimicked. If a "behavioral profile" is assessed, itemize the parameters and scoring system that will be used. Describe animal husbandry, particularly when husbandry methods will impact results. Indicate what will happen to animals when the study is complete.

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